Due to the advent of next-generation sequencing, the field of AHC genetics has been evolving very rapidly over the past two years. Over the last month, five very noteworthy articles were published. Great work is being done to advance the science behind AHC and we are very grateful to the many physicians and researchers taking on this important work.
Brashear, Ozelius, Sweadner “APT1A3 Mutations: What is the Phenotype?” Neurology, Jan 15, 2014.
Hoei-Hansen, Dali, Lyngbye, Duno, Uldall. “Alternating Hemiplegia of Childhood in Denmark: Clinical Manifestations and ATP1A3 Mutation Status.” Eur J Paediatr Neurol, Jan 2014.
Kirshenbaum, Burgess, Dery, Fahnestock, Peever, and Roder. “Attenuation of Mania-Like Behavior in Na(+),K(+)-ATPase a3 Mutant Mice by Prospective Therapies for Bipolar Disorder: Melatonin and Exercise.” Neuroscience, Feb 28, 2014.
Novy, McWilliams, and Sisodiya “Asystole in Alternating Hemiplegia with De Novo ATP1A3 Mutation.” Eur J Med Genet, Jan 2014.
Sasaki, Ishii, Saito, Morisada, et al. “Genotype-Phenotype Correlations in Alternating Hemiplegia of Childhood.” Neurology, Jan 15, 2014.